Quotes by David Sinclair

“In my mind, there are few sins so egregious as extending life without health. This is important. It does not matter if we can extend lifespans if we cannot extend healthspans to an equal extent. And so if we’re going to do the former, we have an absolute moral obligation to do the latter.””

“The first principle is that you must not fool yourself”

“Zarathustra is the prophet of the Church of the Serpent. He himself was distinctly serpentine. Nietzsche is one of the snake philosophers. He has venom towards the weak and the meek. He has the fierce bite of knowledge. We all need the Serpent’s Kiss if we wish to become enlightened. You must poison your old self if you wish to find your new self, your higher self. Your old views are poisonous. Poison must meet poison.””

“Every hero needs to venture into the Belly of the Beast. It’s essential to be devoured at least once by the monster. The hero never begins as a hero. He becomes a hero, and that entails the annihilation of his own, unheroic, former self. The hero always undergoes a metamorphosis, from ordinary to extraordinary. The hero, like the snake, sheds its old skin and takes on a new form. To change, you must enter a sacred space, a transformational space. Nothing ever changes in the ordinary space. The familiar world keeps you the same. It has no alchemical power. If you are confined in the same old world, you remain the same old person. You must cross the threshold into the New World.””

“The Soviet Union never ended. It reformed itself as the Woke West, a totalitarian liberal, rather than communist, nightmare. Big Brother became Non-Binary Elder Sibling.””

“Youth → broken DNA → genome instability → disruption of DNA packaging and gene regulation (the epigenome) → loss of cell identity → cellular senescence → disease → death.””

“The longevity genes I work on are called “sirtuins,” named after the yeast SIR2 gene, the first one to be discovered. There are seven sirtuins in mammals, SIRT1 to SIRT7, and they are made by almost every cell in the body. When I started my research, sirtuins were barely on the scientific radar. Now this family of genes is at the forefront of medical research and drug development. Descended from gene B in M. superstes, sirtuins are enzymes that remove acetyl tags from histones and other proteins and, by doing so, change the packaging of the DNA, turning genes off and on when needed. These critical epigenetic regulators sit at the very top of cellular control systems, controlling our reproduction and our DNA repair. After a few billion years of advancement since the days of yeast, they have evolved to control our health, our fitness, and our very survival. They have also evolved to require a molecule called nicotinamide adenine dinucleotide, or NAD. As we will see later, the loss of NAD as we age, and the resulting decline in sirtuin activity, is thought to be a primary reason our bodies develop diseases when we are old but not when we are young.””

“The happiness equation, it seems, is to be stupid, unconscious, and a slave to God. Then God will love you and everything will be perfect. It’s amazing how many people love that equation. It’s basically the equation that rules the lives of dogs! If you want to keep your freedom then you must kill God! That’s the only way. God must die so that God may live – the new God. To repeat, God is dead, long live the new God.””

“People doom and damn themselves with their own perverse and pessimistic beliefs about reality.””

“Look at a dog on a leash. This monstrous, abject “pet” used to be a magnificent, powerful, proud wolf. Now it’s a joke. That’s what human interference with carnivorous nature achieves – the opposite of evolution, the removal of animals from vibrant nature to make them pathetic, enfeebled playthings and projections of human beings, with all their crazy neuroses and subjective mental traumas. The example of dogs should provide a horrific warning from history of how strong animals can be turned by humans into the most pathetic creatures.””

“We are the Overcomers, the Overmen, not the Last Men. The Last Men want a petty, trivial, comfortable world without any suffering. Fuck ‘em! The task is not to eliminate suffering, but to sublimate it. All people who accomplish anything great impose tremendous discipline, suffering, and hardship on themselves. They deny themselves an easy, hedonistic life. They train hard, study hard, try hard, make tremendous sacrifices. They’re certainly not in the Last Man game of removing suffering from their life. They don’t want to end suffering. They want to use suffering to develop.””

“I take 1 gram (1,000 mg) of NMN every morning, along with 1 gram of resveratrol (shaken into my homemade yogurt) and 1 gram of metformin.7 • I take a daily dose of vitamin D, vitamin K2, and 83 mg of aspirin. • I strive to keep my sugar, bread, and pasta intake as low as possible. I gave up desserts at age 40, though I do steal tastes. • I try to skip one meal a day or at least make it really small. My busy schedule almost always means that I miss lunch most days of the week. • Every few months, a phlebotomist comes to my home to draw my blood, which I have analyzed for dozens of biomarkers. When my levels of various markers are not optimal, I moderate them with food or exercise. • I try to take a lot of steps each day and walk upstairs, and I go to the gym most weekends with my son, Ben; we lift weights, jog a bit, and hang out in the sauna before dunking in an ice-cold pool. • I eat a lot of plants and try to avoid eating other mammals, even though they do taste good. If I work out, I will eat meat. • I don’t smoke. I try to avoid microwaved plastic, excessive UV exposure, X-rays, and CT scans. • I try to stay on the cool side during the day and when I sleep at night. • I aim to keep my body weight or BMI in the optimal range for healthspan, which for me is 23 to 25.””

“who could blame them if they said "the hell with the rest of the world." Let somebody else buy the bonds. Let somebody else build or repair foreign dams, or design foreign buildings that won't shake apart in earthquakes." When the railways of France, and Germany, and India were breaking down through age, it was the Americans who rebuilt them. When the Pennsylvania Railroad and the New York Central went broke, nobody loaned them an old caboose. Both of 'em are still broke. I can name to you 5,000 times when the Americans raced to the help of other people in trouble. Can you name to me even one time when someone else raced to the Americans in trouble? I don't think there was outside help even during the San Francisco earthquake. Our neighbors have faced it alone, and I am one Canadian who is damned tired of hearing them kicked around. They'll come out of this thing with their flag high. And when they do, they're entitled to thumb their noses at the lands that are gloating over their present troubles. I hope Canada is not one of these. But there are many smug, self-righteous Canadians. And finally, the American Red Cross was told at its 48th Annual meeting in New Orleans this morning that it was broke. This year's disasters -- with the year less than half-over -- has taken it all. And nobody, but nobody, has helped. -  Gordon Sinclair via Radio Broadcast June 5, 1973 from Ontario, Canada””