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1865
Claude Bernard
1865
A scientific publication written in the mid-19th century. This foundational work explores the principles of experimental medicine, emphasizing the necessity of observation and experimentation in understanding physiological and pathological phenomena. Bernard aims to define a scientific approach to medicine, stressing the importance of the methodical investigation of life processes in order to form a comprehensive medical science. The opening of the text establishes the historic struggle of medicine to understand health and disease, highlighting the transition from empirical practices to more systematic, experimental methodologies. It discusses the evolution of medical practice, the value of physiological knowledge, and the critical role of rigorous experimental investigation in establishing accurate medical knowledge. Bernard delineates the distinction between observation and experiment, arguing that while observation reveals natural phenomena, experimentation actively engages with those phenomena to uncover deeper truths about the workings of the body in health and disease. Through this introduction, he sets the stage for a methodologically sound approach to medical research that intertwines theory and practical application.